Toxic mechanisms of Roth801, Canals, microparticles and nanoparticles of ZnO on MG-63 osteoblasts.
Identifieur interne : 000002 ( Main/Exploration ); précédent : 000001; suivant : 000003Toxic mechanisms of Roth801, Canals, microparticles and nanoparticles of ZnO on MG-63 osteoblasts.
Auteurs : Mei-Chi Chang [Taïwan] ; Chia-Mei Tang [Taïwan] ; Yu-Heng Lin [Taïwan] ; Hsin-Cheng Liu [Taïwan] ; Tong-Mei Wang [Taïwan] ; Wen-Chien Lan [Taïwan] ; Ru-Hsiu Cheng [Taïwan] ; Yan-Ru Lin [Taïwan] ; Hsiao-Hua Chang [Taïwan] ; Jiiang-Huei Jeng [Taïwan]Source :
- Materials science & engineering. C, Materials for biological applications [ 1873-0191 ] ; 2021.
Descripteurs français
- KwdFr :
- MESH :
English descriptors
- KwdEn :
- MESH :
- chemical : Zinc Oxide.
- Nanoparticles, Osteoblasts, Phosphorylation, Signal Transduction.
Abstract
ZnO eugenol-based materials are widely used for restoration of caries cavity, apical retrograde filling and root canal sealer. Their effects on apical bone healing await investigation. The toxic mechanisms of ZnO particles and nanoparticles to MG-63 osteoblastic cells were studied. We found the different morphology and size of various particles as observed by scanning electron microscope. Particles of Canals and Roth801 were larger than ZnO-205532 microparticles and ZnO-677450 nanoparticles. Four ZnO particles showed cytotoxicity (>25 μg/ml) as analyzed by MTT. Transmission electron microscope found intracellular vacuoles with particle content. Exposure to ZnO particles induced ROS production and cell cycle arrest as studied by DCF and propidium iodide flow cytometry. ZnO particles activated ATM, ATR, Chk1, Chk2, γ-H2AX, ERK and p38 phosphorylation as detected by immunofluorescent staining and western blotting. The protein expression of cdc2, cyclin B1 and cdc25C were decreased, whereas GADD45α and hemeoxygenase-1 (HO-1) were stimulated. ZnO particles' cytotoxicity to MG63 cells was prevented by N-acetylcysteine (NAC), but not CGK733, AZD7762, U0126 and SB203580. ZnO showed little effect on IL-8 and sICAM-1 secretion. These results indicated that ZnO particles are toxic to osteoblasts. ZnO particles' toxicity were related to ROS, and DNA damage responses, checkpoint kinases, cell cycle arrest, ERK and p38 signaling, but not IL-8 and ICAM-1. These results were useful for materials' development and promote apical healing. Dentists should avoid of extruding ZnO-based sealers excessively over root apex and prevent residual ZnO-based retrograde filling materials in apical area during endodontic practice.
DOI: 10.1016/j.msec.2020.111635
PubMed: 33321673
Affiliations:
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Electronic address: hhchangpedo@gmail.com.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Jeng, Jiiang Huei" sort="Jeng, Jiiang Huei" uniqKey="Jeng J" first="Jiiang-Huei" last="Jeng">Jiiang-Huei Jeng</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. 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Department of Dentistry, Chang Gung Memorial Hospital, Linkou, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Chang Gung University of Science and Technology, Kwei-Shan, Taoyuan, Taiwan; Department of Dentistry, Chang Gung Memorial Hospital, Linkou</wicri:regionArea><wicri:noRegion>Linkou</wicri:noRegion></affiliation></author><author><name sortKey="Tang, Chia Mei" sort="Tang, Chia Mei" uniqKey="Tang C" first="Chia-Mei" last="Tang">Chia-Mei Tang</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yu Heng" sort="Lin, Yu Heng" uniqKey="Lin Y" first="Yu-Heng" last="Lin">Yu-Heng Lin</name><affiliation wicri:level="1"><nlm:affiliation>Department of Dentistry, Chang Gung Memorial Hospital, Linkou, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Dentistry, Chang Gung Memorial Hospital, Linkou</wicri:regionArea><wicri:noRegion>Linkou</wicri:noRegion></affiliation></author><author><name sortKey="Liu, Hsin Cheng" sort="Liu, Hsin Cheng" uniqKey="Liu H" first="Hsin-Cheng" last="Liu">Hsin-Cheng Liu</name><affiliation wicri:level="1"><nlm:affiliation>Wei-Cheng Dental Group, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Wei-Cheng Dental Group, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Wang, Tong Mei" sort="Wang, Tong Mei" uniqKey="Wang T" first="Tong-Mei" last="Wang">Tong-Mei Wang</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lan, Wen Chien" sort="Lan, Wen Chien" uniqKey="Lan W" first="Wen-Chien" last="Lan">Wen-Chien Lan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Oral Hygiene Care, Ching Kuo Institute of Management & Health, Keelong, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>Department of Oral Hygiene Care, Ching Kuo Institute of Management & Health, Keelong</wicri:regionArea><wicri:noRegion>Keelong</wicri:noRegion></affiliation></author><author><name sortKey="Cheng, Ru Hsiu" sort="Cheng, Ru Hsiu" uniqKey="Cheng R" first="Ru-Hsiu" last="Cheng">Ru-Hsiu Cheng</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Lin, Yan Ru" sort="Lin, Yan Ru" uniqKey="Lin Y" first="Yan-Ru" last="Lin">Yan-Ru Lin</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Chang, Hsiao Hua" sort="Chang, Hsiao Hua" uniqKey="Chang H" first="Hsiao-Hua" last="Chang">Hsiao-Hua Chang</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: hhchangpedo@gmail.com.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei</wicri:regionArea><wicri:noRegion>Taipei</wicri:noRegion></affiliation></author><author><name sortKey="Jeng, Jiiang Huei" sort="Jeng, Jiiang Huei" uniqKey="Jeng J" first="Jiiang-Huei" last="Jeng">Jiiang-Huei Jeng</name><affiliation wicri:level="1"><nlm:affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: jhjeng@ntu.edu.tw.</nlm:affiliation><country xml:lang="fr">Taïwan</country><wicri:regionArea>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung</wicri:regionArea><wicri:noRegion>Kaohsiung</wicri:noRegion></affiliation></author></analytic><series><title level="j">Materials science & engineering. C, Materials for biological applications</title><idno type="eISSN">1873-0191</idno><imprint><date when="2021" type="published">2021</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Nanoparticles (MeSH)</term><term>Osteoblasts (MeSH)</term><term>Phosphorylation (MeSH)</term><term>Signal Transduction (MeSH)</term><term>Zinc Oxide (MeSH)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Nanoparticules (MeSH)</term><term>Ostéoblastes (MeSH)</term><term>Oxyde de zinc (MeSH)</term><term>Phosphorylation (MeSH)</term><term>Transduction du signal (MeSH)</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Zinc Oxide</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Nanoparticles</term><term>Osteoblasts</term><term>Phosphorylation</term><term>Signal Transduction</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Nanoparticules</term><term>Ostéoblastes</term><term>Oxyde de zinc</term><term>Phosphorylation</term><term>Transduction du signal</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">ZnO eugenol-based materials are widely used for restoration of caries cavity, apical retrograde filling and root canal sealer. Their effects on apical bone healing await investigation. The toxic mechanisms of ZnO particles and nanoparticles to MG-63 osteoblastic cells were studied. We found the different morphology and size of various particles as observed by scanning electron microscope. Particles of Canals and Roth801 were larger than ZnO-205532 microparticles and ZnO-677450 nanoparticles. Four ZnO particles showed cytotoxicity (>25 μg/ml) as analyzed by MTT. Transmission electron microscope found intracellular vacuoles with particle content. Exposure to ZnO particles induced ROS production and cell cycle arrest as studied by DCF and propidium iodide flow cytometry. ZnO particles activated ATM, ATR, Chk1, Chk2, γ-H2AX, ERK and p38 phosphorylation as detected by immunofluorescent staining and western blotting. The protein expression of cdc2, cyclin B1 and cdc25C were decreased, whereas GADD45α and hemeoxygenase-1 (HO-1) were stimulated. ZnO particles' cytotoxicity to MG63 cells was prevented by N-acetylcysteine (NAC), but not CGK733, AZD7762, U0126 and SB203580. ZnO showed little effect on IL-8 and sICAM-1 secretion. These results indicated that ZnO particles are toxic to osteoblasts. ZnO particles' toxicity were related to ROS, and DNA damage responses, checkpoint kinases, cell cycle arrest, ERK and p38 signaling, but not IL-8 and ICAM-1. These results were useful for materials' development and promote apical healing. Dentists should avoid of extruding ZnO-based sealers excessively over root apex and prevent residual ZnO-based retrograde filling materials in apical area during endodontic practice.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" IndexingMethod="Automated" Owner="NLM"><PMID Version="1">33321673</PMID><DateCompleted><Year>2021</Year><Month>05</Month><Day>14</Day></DateCompleted><DateRevised><Year>2021</Year><Month>05</Month><Day>14</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1873-0191</ISSN><JournalIssue CitedMedium="Internet"><Volume>119</Volume><PubDate><Year>2021</Year><Month>Feb</Month></PubDate></JournalIssue><Title>Materials science & engineering. C, Materials for biological applications</Title><ISOAbbreviation>Mater Sci Eng C Mater Biol Appl</ISOAbbreviation></Journal><ArticleTitle>Toxic mechanisms of Roth801, Canals, microparticles and nanoparticles of ZnO on MG-63 osteoblasts.</ArticleTitle><Pagination><MedlinePgn>111635</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">S0928-4931(20)33553-0</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1016/j.msec.2020.111635</ELocationID><Abstract><AbstractText>ZnO eugenol-based materials are widely used for restoration of caries cavity, apical retrograde filling and root canal sealer. Their effects on apical bone healing await investigation. The toxic mechanisms of ZnO particles and nanoparticles to MG-63 osteoblastic cells were studied. We found the different morphology and size of various particles as observed by scanning electron microscope. Particles of Canals and Roth801 were larger than ZnO-205532 microparticles and ZnO-677450 nanoparticles. Four ZnO particles showed cytotoxicity (>25 μg/ml) as analyzed by MTT. Transmission electron microscope found intracellular vacuoles with particle content. Exposure to ZnO particles induced ROS production and cell cycle arrest as studied by DCF and propidium iodide flow cytometry. ZnO particles activated ATM, ATR, Chk1, Chk2, γ-H2AX, ERK and p38 phosphorylation as detected by immunofluorescent staining and western blotting. The protein expression of cdc2, cyclin B1 and cdc25C were decreased, whereas GADD45α and hemeoxygenase-1 (HO-1) were stimulated. ZnO particles' cytotoxicity to MG63 cells was prevented by N-acetylcysteine (NAC), but not CGK733, AZD7762, U0126 and SB203580. ZnO showed little effect on IL-8 and sICAM-1 secretion. These results indicated that ZnO particles are toxic to osteoblasts. ZnO particles' toxicity were related to ROS, and DNA damage responses, checkpoint kinases, cell cycle arrest, ERK and p38 signaling, but not IL-8 and ICAM-1. These results were useful for materials' development and promote apical healing. Dentists should avoid of extruding ZnO-based sealers excessively over root apex and prevent residual ZnO-based retrograde filling materials in apical area during endodontic practice.</AbstractText><CopyrightInformation>Copyright © 2020 Elsevier B.V. All rights reserved.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Mei-Chi</ForeName><Initials>MC</Initials><AffiliationInfo><Affiliation>Chang Gung University of Science and Technology, Kwei-Shan, Taoyuan, Taiwan; Department of Dentistry, Chang Gung Memorial Hospital, Linkou, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tang</LastName><ForeName>Chia-Mei</ForeName><Initials>CM</Initials><AffiliationInfo><Affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yu-Heng</ForeName><Initials>YH</Initials><AffiliationInfo><Affiliation>Department of Dentistry, Chang Gung Memorial Hospital, Linkou, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Liu</LastName><ForeName>Hsin-Cheng</ForeName><Initials>HC</Initials><AffiliationInfo><Affiliation>Wei-Cheng Dental Group, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wang</LastName><ForeName>Tong-Mei</ForeName><Initials>TM</Initials><AffiliationInfo><Affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lan</LastName><ForeName>Wen-Chien</ForeName><Initials>WC</Initials><AffiliationInfo><Affiliation>Department of Oral Hygiene Care, Ching Kuo Institute of Management & Health, Keelong, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Cheng</LastName><ForeName>Ru-Hsiu</ForeName><Initials>RH</Initials><AffiliationInfo><Affiliation>School of Dentistry, College of Oral Medicine, Taipei Medical University, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Yan-Ru</ForeName><Initials>YR</Initials><AffiliationInfo><Affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Chang</LastName><ForeName>Hsiao-Hua</ForeName><Initials>HH</Initials><AffiliationInfo><Affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan. Electronic address: hhchangpedo@gmail.com.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jeng</LastName><ForeName>Jiiang-Huei</ForeName><Initials>JH</Initials><AffiliationInfo><Affiliation>School of Dentistry, National Taiwan University Medical College, Taipei, Taiwan; Department of Dentistry, National Taiwan University Hospital, Taipei, Taiwan; School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan; Department of Dentistry, Kaohsiung Medical University Hospital, Kaohsiung, Taiwan. Electronic address: jhjeng@ntu.edu.tw.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2020</Year><Month>10</Month><Day>17</Day></ArticleDate></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Mater Sci Eng C Mater Biol Appl</MedlineTA><NlmUniqueID>101484109</NlmUniqueID><ISSNLinking>0928-4931</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>SOI2LOH54Z</RegistryNumber><NameOfSubstance UI="D015034">Zinc Oxide</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D053758" MajorTopicYN="Y">Nanoparticles</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010006" MajorTopicYN="N">Osteoblasts</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D010766" MajorTopicYN="N">Phosphorylation</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015398" MajorTopicYN="N">Signal Transduction</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015034" MajorTopicYN="Y">Zinc Oxide</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Endodontic treatment</Keyword><Keyword MajorTopicYN="N">Nanoparticles</Keyword><Keyword MajorTopicYN="N">Osteoblasts</Keyword><Keyword MajorTopicYN="N">Signal transduction</Keyword><Keyword MajorTopicYN="N">Toxicity</Keyword><Keyword MajorTopicYN="N">ZnO particles</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2020</Year><Month>06</Month><Day>25</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2020</Year><Month>10</Month><Day>08</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2020</Year><Month>10</Month><Day>12</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2020</Year><Month>12</Month><Day>16</Day><Hour>1</Hour><Minute>1</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2020</Year><Month>12</Month><Day>17</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2021</Year><Month>5</Month><Day>15</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">33321673</ArticleId><ArticleId IdType="pii">S0928-4931(20)33553-0</ArticleId><ArticleId IdType="doi">10.1016/j.msec.2020.111635</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Taïwan</li></country></list><tree><country name="Taïwan"><noRegion><name sortKey="Chang, Mei Chi" sort="Chang, Mei Chi" uniqKey="Chang M" first="Mei-Chi" last="Chang">Mei-Chi Chang</name></noRegion><name sortKey="Chang, Hsiao Hua" sort="Chang, Hsiao Hua" uniqKey="Chang H" first="Hsiao-Hua" last="Chang">Hsiao-Hua Chang</name><name sortKey="Cheng, Ru Hsiu" sort="Cheng, Ru Hsiu" uniqKey="Cheng R" first="Ru-Hsiu" last="Cheng">Ru-Hsiu Cheng</name><name sortKey="Jeng, Jiiang Huei" sort="Jeng, Jiiang Huei" uniqKey="Jeng J" first="Jiiang-Huei" last="Jeng">Jiiang-Huei Jeng</name><name sortKey="Lan, Wen Chien" sort="Lan, Wen Chien" uniqKey="Lan W" first="Wen-Chien" last="Lan">Wen-Chien Lan</name><name sortKey="Lin, Yan Ru" sort="Lin, Yan Ru" uniqKey="Lin Y" first="Yan-Ru" last="Lin">Yan-Ru Lin</name><name sortKey="Lin, Yu Heng" sort="Lin, Yu Heng" uniqKey="Lin Y" first="Yu-Heng" last="Lin">Yu-Heng Lin</name><name sortKey="Liu, Hsin Cheng" sort="Liu, Hsin Cheng" uniqKey="Liu H" first="Hsin-Cheng" last="Liu">Hsin-Cheng Liu</name><name sortKey="Tang, Chia Mei" sort="Tang, Chia Mei" uniqKey="Tang C" first="Chia-Mei" last="Tang">Chia-Mei Tang</name><name sortKey="Wang, Tong Mei" sort="Wang, Tong Mei" uniqKey="Wang T" first="Tong-Mei" last="Wang">Tong-Mei Wang</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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